Buprenorphine Caused Opiate Withdrawal in Clinical Trial
I was looking around the other day for information about what happens when you mess around with your Suboxone prescription or try and take it other than prescribed. We’ve talked a little bit about the effects of Suboxone and how the naloxone sends you into opiate withdrawal if you try to dissolve the tablet and inject it. But here’s a case of the same result—opiate withdrawal—when someone tried to skip a few days and stockpile their buprenorphine pills then take them all at once to get high. Here’s a quote from the discussion at the Medical Journal of Australia:
The Buprenorphine-Spawned Opiate Withdrawal Incident
By diverting his dispensed medication, our patient collected 11 buprenorphine tablets (8 mg each), which he took in one day. The result was not respiratory depression, but instead severe opiate withdrawal lasting four days — this scenario has not previously been reported. This case highlights features of the unique pharmacology of buprenorphine and some key issues for its use in the management of heroin dependence.
Yikes. No bueno. But I can understand his logic behind it. Usually backing off your drug of choice for a few days can help you feel it a little stronger when you take it again, right? Especially if you take it in such a large dose. But bupe ain’t your average opiate, apparently. I’m completely intrigued by what they call buprenorphine’s “unique pharmacology.”
The Burning Question of Buprenorphine-Caused Opiate Withdrawal
Now, I’m assuming that this person took Suboxone and not Subutex and that the naloxone must have kicked in for some reason. I’m also assuming that he took that as per usual, that is letting them dissolve under his tongue rather than injecting the drug. Because if he injected it, there is no mystery. Or if he took other opiates (heroin was his drug of choice and apparently there were some relapse incidents, though it doesn’t say how many days passed between relapse and restarting his buprenorphine regimen) and then took Suboxone without waiting for the detox to begin, that makes sense, too. But if they were Suboxone pills and he took them as prescribed or if they were Subutex pills and he took them in any form at any time after relapse, then I simply must know why this happened.
What Do You Think?
Anyone have any ideas? Theories? Perhaps experiences of your own that may illuminate this quandary?
Incidentally, the person in question was transferred to methadone treatment and his withdrawal subsided when buprenorphine wouldn’t ease his symptoms. Just goes to show that buprenorphine isn’t right for everyone and that methadone and other opiate detox methods are still viable and valuable.



